Data from Sophie’s samples (human cells)
Conditions: treated w/ or w/o H2O2
Biological replicates (4, each at a different date)
Gene set enrichment analysis using - pval < 0,05 - pval < 0,001
| ID | setSize | NES | p.adjust | qvalue |
|---|---|---|---|---|
| GOBP_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT | 182 | 2.158904 | 0.0010628 | 0.0009356 |
| GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT | 55 | 2.377661 | 0.0013660 | 0.0012024 |
| GOBP_RESPONSE_TO_PURINE_CONTAINING_COMPOUND | 23 | 2.328951 | 0.0091467 | 0.0080518 |
| GOBP_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | 37 | 2.278847 | 0.0091467 | 0.0080518 |
| GOBP_POSITIVE_REGULATION_OF_LOCOMOTION | 107 | 2.116812 | 0.0091467 | 0.0080518 |
| GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION | 71 | 2.101033 | 0.0091467 | 0.0080518 |
| GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II | 286 | 1.805991 | 0.0091467 | 0.0080518 |
| GOBP_CELL_MIGRATION | 263 | 1.793768 | 0.0091467 | 0.0080518 |
| GOBP_TISSUE_MIGRATION | 53 | 2.192531 | 0.0093384 | 0.0082206 |
| GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS | 347 | 1.728661 | 0.0093384 | 0.0082206 |
| GOBP_MATERNAL_PLACENTA_DEVELOPMENT | 12 | 2.234071 | 0.0097947 | 0.0086223 |
| GOBP_NERVOUS_SYSTEM_PROCESS | 149 | -1.975748 | 0.0097947 | 0.0086223 |
| GOBP_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS | 285 | 1.752879 | 0.0097947 | 0.0086223 |
| GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT | 30 | 2.252706 | 0.0103605 | 0.0091204 |
| GOBP_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY | 16 | 2.186883 | 0.0103605 | 0.0091204 |
| GOBP_OXIDATIVE_PHOSPHORYLATION | 74 | -2.121510 | 0.0103605 | 0.0091204 |
| GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION | 118 | 1.934489 | 0.0103605 | 0.0091204 |
| GOBP_TRANSMEMBRANE_TRANSPORT | 289 | -1.727893 | 0.0103605 | 0.0091204 |
| GOBP_LOCOMOTION | 330 | 1.701054 | 0.0103605 | 0.0091204 |
| GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | 27 | 2.220117 | 0.0113617 | 0.0100017 |
| GOBP_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS | 462 | 1.611512 | 0.0118857 | 0.0104630 |
| GOBP_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY | 31 | -2.233059 | 0.0125085 | 0.0110112 |
| GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS | 167 | 1.856175 | 0.0160352 | 0.0141158 |
| GOBP_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT | 150 | -1.907533 | 0.0166576 | 0.0146637 |
| GOBP_INFLAMMATORY_RESPONSE | 149 | 1.872661 | 0.0166576 | 0.0146637 |
| GOBP_ION_TRANSMEMBRANE_TRANSPORT | 202 | -1.833908 | 0.0166576 | 0.0146637 |
| GOBP_NEURON_PROJECTION_GUIDANCE | 20 | -2.222593 | 0.0169168 | 0.0148919 |
| GOBP_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE | 32 | -2.238387 | 0.0169425 | 0.0149145 |
| GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS | 167 | 1.840059 | 0.0169425 | 0.0149145 |
| GOBP_PROTON_TRANSMEMBRANE_TRANSPORT | 56 | -2.059081 | 0.0180886 | 0.0159234 |
| GOBP_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY | 24 | 2.102521 | 0.0186570 | 0.0164237 |
| GOBP_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY | 50 | -2.088816 | 0.0186570 | 0.0164237 |
| GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS | 181 | 1.811724 | 0.0186570 | 0.0164237 |
| GOBP_SENSORY_PERCEPTION | 75 | -1.997401 | 0.0192393 | 0.0169363 |
| GOBP_EPITHELIAL_CELL_PROLIFERATION | 63 | 2.008819 | 0.0209139 | 0.0184105 |
| GOBP_STRIATED_MUSCLE_CELL_PROLIFERATION | 12 | 2.116013 | 0.0212855 | 0.0187377 |
| GOBP_RESPONSE_TO_STEROID_HORMONE | 85 | 1.912972 | 0.0221553 | 0.0195033 |
| GOBP_RESPONSE_TO_CAMP | 14 | 2.129923 | 0.0250854 | 0.0220826 |
| GOBP_TISSUE_REGENERATION | 16 | 2.085994 | 0.0250854 | 0.0220826 |
| GOBP_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT | 14 | -2.158991 | 0.0253989 | 0.0223586 |
| GOBP_ATP_BIOSYNTHETIC_PROCESS | 23 | -2.127332 | 0.0253989 | 0.0223586 |
| GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION | 87 | 1.946354 | 0.0253989 | 0.0223586 |
| GOBP_DEVELOPMENTAL_GROWTH | 120 | 1.857243 | 0.0253989 | 0.0223586 |
| GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS | 345 | 1.569007 | 0.0253989 | 0.0223586 |
| GOBP_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT | 11 | -2.076761 | 0.0264326 | 0.0232686 |
| GOBP_ENDOTHELIAL_CELL_MIGRATION | 39 | 2.043009 | 0.0269058 | 0.0236852 |
| GOBP_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE | 18 | 2.110079 | 0.0273758 | 0.0240989 |
| GOBP_RESPONSE_TO_LEUKEMIA_INHIBITORY_FACTOR | 27 | 2.076573 | 0.0273758 | 0.0240989 |
| GOBP_POSITIVE_REGULATION_OF_MIRNA_TRANSCRIPTION | 11 | 2.039111 | 0.0273758 | 0.0240989 |
| GOBP_NEGATIVE_REGULATION_OF_SIGNALING | 296 | 1.641383 | 0.0273758 | 0.0240989 |
| GOBP_GROWTH | 203 | 1.718381 | 0.0280495 | 0.0246920 |
| GOBP_ION_TRANSPORT | 280 | -1.637008 | 0.0298371 | 0.0262656 |
| GOBP_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM | 17 | -2.120758 | 0.0302557 | 0.0266341 |
| GOBP_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION | 13 | 2.052409 | 0.0302557 | 0.0266341 |
| GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION | 29 | 2.040795 | 0.0302557 | 0.0266341 |
| GOBP_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY | 11 | 2.018056 | 0.0302557 | 0.0266341 |
| GOBP_BLOOD_VESSEL_MORPHOGENESIS | 110 | 1.830568 | 0.0302557 | 0.0266341 |
| GOBP_VASCULATURE_DEVELOPMENT | 131 | 1.829815 | 0.0302557 | 0.0266341 |
| GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION | 122 | 1.812480 | 0.0302557 | 0.0266341 |
| GOBP_RESPONSE_TO_HORMONE | 205 | 1.682103 | 0.0302557 | 0.0266341 |
| GOBP_ANIMAL_ORGAN_MORPHOGENESIS | 138 | 1.747786 | 0.0306542 | 0.0269849 |
| GOBP_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND | 193 | 1.733548 | 0.0306542 | 0.0269849 |
| GOBP_TISSUE_DEVELOPMENT | 348 | 1.542001 | 0.0306542 | 0.0269849 |
| GOBP_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS | 10 | 2.017266 | 0.0322843 | 0.0284199 |
| GOBP_ATP_METABOLIC_PROCESS | 111 | -1.776512 | 0.0344694 | 0.0303434 |
| GOBP_CAMERA_TYPE_EYE_DEVELOPMENT | 44 | 1.927631 | 0.0360847 | 0.0317653 |
| GOBP_SYNAPSE_ORGANIZATION | 71 | -1.835258 | 0.0360847 | 0.0317653 |
| GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS | 232 | 1.623601 | 0.0372352 | 0.0327781 |
| GOBP_CYTOKINE_PRODUCTION | 147 | 1.717746 | 0.0393715 | 0.0346587 |
| GOBP_CATION_TRANSMEMBRANE_TRANSPORT | 155 | -1.750186 | 0.0404780 | 0.0356328 |
| GOBP_POSITIVE_REGULATION_OF_SIGNALING | 341 | 1.555743 | 0.0404780 | 0.0356328 |
| GOBP_RESPONSE_TO_BMP | 28 | 2.066249 | 0.0415626 | 0.0365876 |
| GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION | 28 | 2.058720 | 0.0415626 | 0.0365876 |
| GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT | 258 | 1.581772 | 0.0415626 | 0.0365876 |
| GOBP_REGULATION_OF_RESPONSE_TO_STRESS | 327 | 1.568948 | 0.0415626 | 0.0365876 |
| GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND | 336 | 1.513273 | 0.0415626 | 0.0365876 |
| GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING | 12 | 2.005849 | 0.0462688 | 0.0407304 |
| GOBP_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS | 13 | 1.993177 | 0.0463450 | 0.0407975 |
| GOBP_TUBE_DEVELOPMENT | 199 | 1.653204 | 0.0478627 | 0.0421336 |
| GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS | 197 | 1.641447 | 0.0478627 | 0.0421336 |
| ID | setSize | NES | p.adjust | qvalue |
|---|---|---|---|---|
| GOMF_TRANSPORTER_ACTIVITY | 260 | -2.118267 | 0.0000211 | 0.0000194 |
| GOMF_GATED_CHANNEL_ACTIVITY | 32 | -2.522397 | 0.0001291 | 0.0001189 |
| GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 61 | -2.384464 | 0.0002468 | 0.0002274 |
| GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME | 99 | -2.190401 | 0.0003165 | 0.0002916 |
| GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR | 33 | -2.404862 | 0.0004259 | 0.0003924 |
| GOMF_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 158 | -2.018930 | 0.0007181 | 0.0006617 |
| GOMF_NADH_DEHYDROGENASE_ACTIVITY | 29 | -2.385499 | 0.0009860 | 0.0009085 |
| GOMF_OXIDOREDUCTION_DRIVEN_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 45 | -2.326842 | 0.0009860 | 0.0009085 |
| GOMF_STRUCTURAL_MOLECULE_ACTIVITY | 165 | -2.025739 | 0.0009860 | 0.0009085 |
| GOMF_INORGANIC_MOLECULAR_ENTITY_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 129 | -2.079410 | 0.0013308 | 0.0012262 |
| GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H | 35 | -2.285747 | 0.0015349 | 0.0014142 |
| GOMF_CATION_CHANNEL_ACTIVITY | 43 | -2.217953 | 0.0018225 | 0.0016792 |
| GOMF_VOLTAGE_GATED_CHANNEL_ACTIVITY | 18 | -2.249661 | 0.0035844 | 0.0033026 |
| GOMF_DNA_BINDING_TRANSCRIPTION_ACTIVATOR_ACTIVITY | 84 | 2.024491 | 0.0035844 | 0.0033026 |
| GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 65 | -2.025923 | 0.0075539 | 0.0069600 |
| GOMF_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 117 | -1.899412 | 0.0147191 | 0.0135619 |
| GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 57 | -2.007007 | 0.0162845 | 0.0150042 |
| GOMF_ELECTRON_TRANSFER_ACTIVITY | 61 | -1.882843 | 0.0224650 | 0.0206988 |
| GOMF_PROTON_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 45 | -2.010496 | 0.0240866 | 0.0221929 |
| GOMF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 11 | -1.946241 | 0.0291576 | 0.0268652 |
| GOMF_PROTON_CHANNEL_ACTIVITY | 11 | -1.944536 | 0.0291576 | 0.0268652 |
| GOMF_CARBOHYDRATE_BINDING | 46 | -1.987058 | 0.0292113 | 0.0269147 |
| GOMF_CALMODULIN_BINDING | 31 | -1.998581 | 0.0409216 | 0.0377044 |
| GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT | 15 | -1.987028 | 0.0420049 | 0.0387025 |
| GOMF_SEQUENCE_SPECIFIC_DNA_BINDING | 351 | 1.483450 | 0.0420049 | 0.0387025 |
| GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 102 | -1.739424 | 0.0429357 | 0.0395602 |
| ID | setSize | NES | p.adjust | qvalue |
|---|---|---|---|---|
| REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS | 76 | -2.288355 | 0.0046397 | 0.0045339 |
| REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS | 26 | 2.228044 | 0.0139838 | 0.0136648 |
| REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | 63 | -2.123374 | 0.0139838 | 0.0136648 |
| REACTOME_COMPLEX_I_BIOGENESIS | 34 | -2.239465 | 0.0186163 | 0.0181917 |
| REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION | 38 | -2.197720 | 0.0186163 | 0.0181917 |
| REACTOME_NEURONAL_SYSTEM | 60 | -2.142954 | 0.0186163 | 0.0181917 |
| REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES | 10 | -2.121133 | 0.0186163 | 0.0181917 |
| REACTOME_COLLAGEN_FORMATION | 12 | -2.099965 | 0.0482505 | 0.0471501 |
| ID | setSize | NES | p.adjust | qvalue |
|---|---|---|---|---|
| WP_OXIDATIVE_PHOSPHORYLATION | 41 | -2.456836 | 0.0006087 | 0.0005671 |
| WP_ELECTRON_TRANSPORT_CHAIN_OXPHOS_SYSTEM_IN_MITOCHONDRIA | 68 | -2.294227 | 0.0017982 | 0.0016753 |
| WP_MITOCHONDRIAL_COMPLEX_I_ASSEMBLY_MODEL_OXPHOS_SYSTEM | 33 | -2.229192 | 0.0047706 | 0.0044447 |
| WP_GLUCOCORTICOID_RECEPTOR_PATHWAY | 25 | 2.156775 | 0.0087083 | 0.0081134 |
| WP_NUCLEAR_RECEPTORS_METAPATHWAY | 78 | 1.860052 | 0.0282192 | 0.0262916 |
| WP_GPCRS_CLASS_A_RHODOPSINLIKE | 20 | 1.999252 | 0.0377677 | 0.0351878 |
| ID | setSize | NES | p.adjust | qvalue |
|---|---|---|---|---|
| GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II | 186 | 2.520542 | 0.0000023 | 0.0000018 |
| GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION | 68 | 2.732333 | 0.0000192 | 0.0000149 |
| GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS | 98 | 2.559629 | 0.0000753 | 0.0000586 |
| GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS | 220 | 2.246038 | 0.0000837 | 0.0000652 |
| GOBP_TISSUE_DEVELOPMENT | 210 | 2.240807 | 0.0000837 | 0.0000652 |
| GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS | 106 | 2.493975 | 0.0001032 | 0.0000804 |
| GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS | 208 | 2.242375 | 0.0001032 | 0.0000804 |
| GOBP_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS | 179 | 2.257974 | 0.0001886 | 0.0001468 |
| GOBP_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY | 31 | -2.902267 | 0.0002193 | 0.0001707 |
| GOBP_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS | 294 | 2.060742 | 0.0002245 | 0.0001748 |
| GOBP_POSITIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS | 334 | 2.015989 | 0.0003228 | 0.0002513 |
| GOBP_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT | 116 | 2.314863 | 0.0003512 | 0.0002734 |
| GOBP_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY | 20 | -2.715416 | 0.0003646 | 0.0002838 |
| GOBP_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | 12 | 2.497623 | 0.0003646 | 0.0002838 |
| GOBP_CELL_MIGRATION | 150 | 2.206405 | 0.0003646 | 0.0002838 |
| GOBP_NEGATIVE_REGULATION_OF_SIGNALING | 190 | 2.145443 | 0.0003646 | 0.0002838 |
| GOBP_OXIDATIVE_PHOSPHORYLATION | 58 | -2.618687 | 0.0006103 | 0.0004751 |
| GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS | 102 | 2.275272 | 0.0007678 | 0.0005978 |
| GOBP_TUBE_DEVELOPMENT | 112 | 2.261188 | 0.0007678 | 0.0005978 |
| GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT | 150 | 2.151771 | 0.0007678 | 0.0005978 |
| GOBP_LOCOMOTION | 187 | 2.113294 | 0.0007727 | 0.0006016 |
| GOBP_RESPONSE_TO_GROWTH_FACTOR | 84 | 2.374888 | 0.0008212 | 0.0006393 |
| GOBP_RESPONSE_TO_MECHANICAL_STIMULUS | 18 | 2.483991 | 0.0009849 | 0.0007668 |
| GOBP_NEUROGENESIS | 177 | 2.084765 | 0.0010523 | 0.0008193 |
| GOBP_CAMERA_TYPE_EYE_DEVELOPMENT | 31 | 2.493461 | 0.0010657 | 0.0008297 |
| GOBP_MESENCHYME_DEVELOPMENT | 29 | 2.410737 | 0.0014483 | 0.0011276 |
| GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION | 196 | 2.048289 | 0.0014646 | 0.0011402 |
| GOBP_POSITIVE_REGULATION_OF_CELLULAR_BIOSYNTHETIC_PROCESS | 326 | 1.831229 | 0.0015698 | 0.0012222 |
| GOBP_NEURON_DIFFERENTIATION | 152 | 2.093241 | 0.0019606 | 0.0015264 |
| GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS | 147 | 2.137894 | 0.0022835 | 0.0017778 |
| GOBP_REGULATION_OF_CELL_DIFFERENTIATION | 173 | 2.035481 | 0.0023444 | 0.0018253 |
| GOBP_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE | 25 | -2.578243 | 0.0023529 | 0.0018318 |
| GOBP_HOMEOSTATIC_PROCESS | 215 | 1.975803 | 0.0023529 | 0.0018318 |
| GOBP_RESPONSE_TO_HORMONE | 125 | 2.092701 | 0.0032108 | 0.0024997 |
| GOBP_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY | 16 | 2.329886 | 0.0035209 | 0.0027412 |
| GOBP_ELECTRON_TRANSPORT_CHAIN | 49 | -2.400410 | 0.0036033 | 0.0028054 |
| GOBP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | 22 | 2.390719 | 0.0036033 | 0.0028054 |
| GOBP_MESENCHYMAL_CELL_DIFFERENTIATION | 26 | 2.380425 | 0.0038034 | 0.0029611 |
| GOBP_SENSORY_ORGAN_DEVELOPMENT | 52 | 2.271837 | 0.0038034 | 0.0029611 |
| GOBP_VASCULATURE_DEVELOPMENT | 79 | 2.148447 | 0.0050353 | 0.0039202 |
| GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND | 208 | 1.919017 | 0.0050353 | 0.0039202 |
| GOBP_ANIMAL_ORGAN_MORPHOGENESIS | 78 | 2.190327 | 0.0051072 | 0.0039762 |
| GOBP_MULTICELLULAR_ORGANISM_REPRODUCTION | 92 | 2.132086 | 0.0051072 | 0.0039762 |
| GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS | 162 | 2.002985 | 0.0051072 | 0.0039762 |
| GOBP_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY | 44 | 2.296290 | 0.0052264 | 0.0040690 |
| GOBP_SKELETAL_SYSTEM_DEVELOPMENT | 51 | 2.209678 | 0.0052264 | 0.0040690 |
| GOBP_SENSORY_SYSTEM_DEVELOPMENT | 38 | 2.225467 | 0.0054976 | 0.0042802 |
| GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION | 75 | 2.155797 | 0.0054976 | 0.0042802 |
| GOBP_RESPIRATORY_ELECTRON_TRANSPORT_CHAIN | 43 | -2.324364 | 0.0057177 | 0.0044515 |
| GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION | 43 | 2.251427 | 0.0057800 | 0.0045000 |
| GOBP_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE | 14 | 2.292658 | 0.0067662 | 0.0052678 |
| GOBP_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS | 13 | 2.267729 | 0.0067662 | 0.0052678 |
| GOBP_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS | 29 | 2.221354 | 0.0067662 | 0.0052678 |
| GOBP_TUBE_MORPHOGENESIS | 87 | 2.137387 | 0.0067662 | 0.0052678 |
| GOBP_ATP_SYNTHESIS_COUPLED_ELECTRON_TRANSPORT | 42 | -2.285038 | 0.0071070 | 0.0055332 |
| GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY | 12 | 2.214943 | 0.0072221 | 0.0056227 |
| GOBP_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT | 12 | -2.378883 | 0.0077794 | 0.0060566 |
| GOBP_EMBRYONIC_MORPHOGENESIS | 67 | 2.108363 | 0.0077794 | 0.0060566 |
| GOBP_RESPONSE_TO_PURINE_CONTAINING_COMPOUND | 12 | 2.207272 | 0.0079176 | 0.0061642 |
| GOBP_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND | 120 | 1.995397 | 0.0086019 | 0.0066970 |
| GOBP_DEVELOPMENTAL_GROWTH | 79 | 2.047713 | 0.0111405 | 0.0086734 |
| GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT | 118 | 2.005901 | 0.0111405 | 0.0086734 |
| GOBP_NEGATIVE_REGULATION_OF_MAPK_CASCADE | 34 | 2.218943 | 0.0112981 | 0.0087961 |
| GOBP_REGULATION_OF_CELL_DEATH | 237 | 1.814680 | 0.0122565 | 0.0095423 |
| GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS | 106 | 1.967618 | 0.0128013 | 0.0099664 |
| GOBP_EPITHELIAL_CELL_APOPTOTIC_PROCESS | 19 | 2.184513 | 0.0135031 | 0.0105128 |
| GOBP_STRIATED_MUSCLE_CELL_PROLIFERATION | 10 | 2.175729 | 0.0139482 | 0.0108593 |
| GOBP_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR | 13 | 2.173198 | 0.0150453 | 0.0117135 |
| GOBP_EPIDERMAL_CELL_DIFFERENTIATION | 23 | 2.203935 | 0.0166580 | 0.0129691 |
| GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS | 159 | 1.862746 | 0.0169462 | 0.0131934 |
| GOBP_SENSORY_ORGAN_MORPHOGENESIS | 22 | 2.181919 | 0.0171615 | 0.0133610 |
| GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS | 35 | 2.130150 | 0.0171615 | 0.0133610 |
| GOBP_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY | 29 | 2.101218 | 0.0171615 | 0.0133610 |
| GOBP_REPRODUCTIVE_SYSTEM_DEVELOPMENT | 64 | 2.057835 | 0.0171615 | 0.0133610 |
| GOBP_IMMUNE_SYSTEM_DEVELOPMENT | 127 | 1.940871 | 0.0171615 | 0.0133610 |
| GOBP_RESPONSE_TO_ABIOTIC_STIMULUS | 152 | 1.875930 | 0.0171615 | 0.0133610 |
| GOBP_ATP_BIOSYNTHETIC_PROCESS | 18 | -2.310544 | 0.0172041 | 0.0133942 |
| GOBP_BLOOD_VESSEL_MORPHOGENESIS | 67 | 2.008110 | 0.0172041 | 0.0133942 |
| GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION | 109 | 1.959445 | 0.0172041 | 0.0133942 |
| GOBP_RESPONSE_TO_OXYGEN_LEVELS | 43 | 2.074108 | 0.0183047 | 0.0142511 |
| GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS | 58 | 2.020766 | 0.0183047 | 0.0142511 |
| GOBP_RESPONSE_TO_LIPID | 104 | 1.915768 | 0.0183047 | 0.0142511 |
| GOBP_HOMEOSTASIS_OF_NUMBER_OF_CELLS | 46 | 2.110086 | 0.0187368 | 0.0145875 |
| GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION | 83 | 2.005431 | 0.0192951 | 0.0150222 |
| GOBP_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE | 14 | 2.148009 | 0.0201646 | 0.0156991 |
| GOBP_CELLULAR_RESPIRATION | 70 | -2.101503 | 0.0210723 | 0.0164058 |
| GOBP_CONNECTIVE_TISSUE_DEVELOPMENT | 29 | 2.049929 | 0.0221556 | 0.0172492 |
| GOBP_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY | 24 | 2.143411 | 0.0231697 | 0.0180387 |
| GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT | 34 | 2.082821 | 0.0231697 | 0.0180387 |
| GOBP_GAMETE_GENERATION | 75 | 1.962863 | 0.0238059 | 0.0185340 |
| GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION | 57 | 1.975841 | 0.0244657 | 0.0190477 |
| GOBP_MULTI_ORGANISM_REPRODUCTIVE_PROCESS | 108 | 1.915803 | 0.0246667 | 0.0192042 |
| GOBP_REGULATION_OF_RESPONSE_TO_STRESS | 213 | 1.741558 | 0.0246667 | 0.0192042 |
| GOBP_PROTON_TRANSMEMBRANE_TRANSPORT | 37 | -2.194737 | 0.0247802 | 0.0192925 |
| GOBP_EXPORT_FROM_CELL | 100 | 1.902364 | 0.0247802 | 0.0192925 |
| GOBP_POSITIVE_REGULATION_OF_CELL_DEATH | 83 | 1.958853 | 0.0251349 | 0.0195687 |
| GOBP_INFLAMMATORY_RESPONSE | 79 | 1.937189 | 0.0251349 | 0.0195687 |
| GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS | 94 | 1.912203 | 0.0281838 | 0.0219424 |
| GOBP_AEROBIC_RESPIRATION | 68 | -2.065190 | 0.0283058 | 0.0220374 |
| GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION | 93 | 1.909516 | 0.0305657 | 0.0237968 |
| GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY | 46 | 2.038982 | 0.0309432 | 0.0240908 |
| GOBP_ATP_METABOLIC_PROCESS | 80 | -1.986259 | 0.0309432 | 0.0240908 |
| GOBP_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM | 11 | -2.170584 | 0.0328693 | 0.0255903 |
| GOBP_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION | 10 | 2.073273 | 0.0328693 | 0.0255903 |
| GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION | 18 | 2.065049 | 0.0336125 | 0.0261689 |
| GOBP_EMBRYONIC_ORGAN_DEVELOPMENT | 44 | 2.052500 | 0.0336125 | 0.0261689 |
| GOBP_DIGESTIVE_SYSTEM_DEVELOPMENT | 12 | 2.008951 | 0.0336125 | 0.0261689 |
| GOBP_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY | 31 | 2.047995 | 0.0339652 | 0.0264435 |
| GOBP_POSITIVE_REGULATION_OF_LOCOMOTION | 62 | 1.987559 | 0.0340929 | 0.0265429 |
| GOBP_EPITHELIAL_CELL_DIFFERENTIATION | 79 | 1.877152 | 0.0347002 | 0.0270157 |
| GOBP_REGIONALIZATION | 27 | 2.077870 | 0.0347593 | 0.0270618 |
| GOBP_MITOCHONDRIAL_TRANSLATION | 27 | -2.135346 | 0.0347906 | 0.0270861 |
| GOBP_FORMATION_OF_PRIMARY_GERM_LAYER | 10 | 2.061688 | 0.0347906 | 0.0270861 |
| GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY | 37 | 2.041454 | 0.0351024 | 0.0273289 |
| GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS | 14 | 2.062521 | 0.0354129 | 0.0275706 |
| GOBP_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA | 37 | 2.030162 | 0.0354129 | 0.0275706 |
| GOBP_PATTERN_SPECIFICATION_PROCESS | 37 | 2.009629 | 0.0354129 | 0.0275706 |
| GOBP_NEURON_DEVELOPMENT | 119 | 1.823696 | 0.0354129 | 0.0275706 |
| GOBP_CHEMICAL_HOMEOSTASIS | 125 | 1.801176 | 0.0354129 | 0.0275706 |
| GOBP_CELL_PROJECTION_ORGANIZATION | 187 | 1.724185 | 0.0354129 | 0.0275706 |
| GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT | 120 | 1.802491 | 0.0367372 | 0.0286016 |
| GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS | 16 | 1.970186 | 0.0369300 | 0.0287518 |
| GOBP_MUSCLE_TISSUE_DEVELOPMENT | 47 | 1.947823 | 0.0369300 | 0.0287518 |
| GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION | 176 | 1.733051 | 0.0369300 | 0.0287518 |
| GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY | 19 | 2.011395 | 0.0376068 | 0.0292787 |
| GOBP_VESICLE_BUDDING_FROM_MEMBRANE | 17 | 1.982380 | 0.0376068 | 0.0292787 |
| GOBP_PLACENTA_DEVELOPMENT | 22 | 1.973725 | 0.0376068 | 0.0292787 |
| GOBP_REGULATION_OF_HEMOPOIESIS | 49 | 1.940625 | 0.0376068 | 0.0292787 |
| GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT | 61 | 1.931273 | 0.0376068 | 0.0292787 |
| GOBP_CYTOKINE_PRODUCTION | 85 | 1.831798 | 0.0376068 | 0.0292787 |
| GOBP_GASTRULATION | 22 | 2.033972 | 0.0379759 | 0.0295660 |
| GOBP_MUSCLE_CELL_PROLIFERATION | 24 | 2.031813 | 0.0379759 | 0.0295660 |
| GOBP_GLIAL_CELL_DIFFERENTIATION | 17 | 2.010595 | 0.0379759 | 0.0295660 |
| GOBP_CELLULAR_RESPONSE_TO_KETONE | 17 | 2.009885 | 0.0379759 | 0.0295660 |
| GOBP_CARDIOCYTE_DIFFERENTIATION | 22 | 1.967948 | 0.0379759 | 0.0295660 |
| GOBP_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS | 17 | 1.967332 | 0.0379759 | 0.0295660 |
| GOBP_CELL_FATE_COMMITMENT | 21 | 1.960722 | 0.0379759 | 0.0295660 |
| GOBP_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY | 11 | 1.959295 | 0.0379759 | 0.0295660 |
| GOBP_RESPONSE_TO_NITROGEN_COMPOUND | 162 | 1.706538 | 0.0379759 | 0.0295660 |
| GOBP_P38MAPK_CASCADE | 10 | 1.943107 | 0.0383725 | 0.0298748 |
| GOBP_GROWTH | 131 | 1.783223 | 0.0383725 | 0.0298748 |
| GOBP_EYE_MORPHOGENESIS | 14 | 1.945231 | 0.0384745 | 0.0299543 |
| GOBP_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY | 27 | 1.957757 | 0.0390816 | 0.0304269 |
| GOBP_EMBRYONIC_ORGAN_MORPHOGENESIS | 27 | 2.037600 | 0.0392192 | 0.0305340 |
| GOBP_RESPONSE_TO_STEROID_HORMONE | 52 | 1.933761 | 0.0392192 | 0.0305340 |
| GOBP_REGENERATION | 23 | 2.038253 | 0.0393878 | 0.0306653 |
| GOBP_RHYTHMIC_PROCESS | 42 | 1.912733 | 0.0393878 | 0.0306653 |
| GOBP_MITOCHONDRION_ORGANIZATION | 115 | -1.826157 | 0.0393878 | 0.0306653 |
| GOBP_REGULATION_OF_CELL_ADHESION | 79 | 1.817432 | 0.0393878 | 0.0306653 |
| GOBP_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | 17 | 1.994817 | 0.0395308 | 0.0307766 |
| GOBP_MAPK_CASCADE | 103 | 1.806639 | 0.0404445 | 0.0314880 |
| GOBP_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING | 65 | 1.866532 | 0.0411553 | 0.0320413 |
| GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY | 41 | 1.916576 | 0.0415834 | 0.0323747 |
| GOBP_RESPONSE_TO_BMP | 18 | 1.998648 | 0.0417595 | 0.0325118 |
| GOBP_MYELOID_CELL_HOMEOSTASIS | 34 | 1.939586 | 0.0419168 | 0.0326343 |
| GOBP_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS | 26 | -2.067213 | 0.0421505 | 0.0328162 |
| GOBP_CARDIAC_VENTRICLE_DEVELOPMENT | 13 | 1.953341 | 0.0421505 | 0.0328162 |
| GOBP_CELL_MORPHOGENESIS | 110 | 1.782037 | 0.0421505 | 0.0328162 |
| GOBP_CYTOCHROME_COMPLEX_ASSEMBLY | 11 | -2.097267 | 0.0423384 | 0.0329625 |
| GOBP_LEUKOCYTE_HOMEOSTASIS | 11 | 2.022166 | 0.0423384 | 0.0329625 |
| GOBP_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | 22 | 1.931923 | 0.0423384 | 0.0329625 |
| GOBP_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS | 27 | 1.929549 | 0.0423384 | 0.0329625 |
| GOBP_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS | 25 | -2.106270 | 0.0424666 | 0.0330623 |
| GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS | 36 | 1.925162 | 0.0424666 | 0.0330623 |
| GOBP_CARDIAC_SEPTUM_DEVELOPMENT | 10 | 1.912676 | 0.0454562 | 0.0353898 |
| GOBP_REGULATION_OF_SECRETION | 66 | 1.832455 | 0.0454562 | 0.0353898 |
| GOBP_EPITHELIUM_DEVELOPMENT | 123 | 1.745447 | 0.0454562 | 0.0353898 |
| GOBP_REPRODUCTION | 171 | 1.655858 | 0.0454562 | 0.0353898 |
| GOBP_HEART_GROWTH | 12 | 1.941074 | 0.0458155 | 0.0356696 |
| GOBP_CAMERA_TYPE_EYE_MORPHOGENESIS | 11 | 1.912970 | 0.0459074 | 0.0357411 |
| GOBP_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | 15 | 1.926190 | 0.0459104 | 0.0357434 |
| GOBP_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS | 10 | 1.909144 | 0.0459918 | 0.0358068 |
| GOBP_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION | 20 | 1.895228 | 0.0459918 | 0.0358068 |
| GOBP_CARDIAC_CHAMBER_MORPHOGENESIS | 10 | 1.976894 | 0.0466138 | 0.0362911 |
| GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT | 19 | 1.909194 | 0.0468622 | 0.0364845 |
| GOBP_SYNAPTIC_SIGNALING | 64 | -1.905223 | 0.0468622 | 0.0364845 |
| GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS | 41 | 1.879225 | 0.0470050 | 0.0365956 |
| GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN | 27 | 1.905341 | 0.0470955 | 0.0366661 |
| GOBP_ENDOTHELIAL_CELL_DEVELOPMENT | 15 | -2.025903 | 0.0471560 | 0.0367132 |
| GOBP_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE | 10 | 1.898611 | 0.0471560 | 0.0367132 |
| GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND | 148 | 1.696419 | 0.0476757 | 0.0371178 |
| GOBP_REGULATION_OF_MITOCHONDRIAL_GENE_EXPRESSION | 10 | -2.039005 | 0.0478544 | 0.0372570 |
| GOBP_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE | 20 | 1.887775 | 0.0478544 | 0.0372570 |
| GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION | 37 | 1.889081 | 0.0486031 | 0.0378399 |
| GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS | 35 | 1.897636 | 0.0492094 | 0.0383119 |
| GOBP_ERK1_AND_ERK2_CASCADE | 33 | 1.892530 | 0.0492094 | 0.0383119 |
| GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION | 33 | 1.891862 | 0.0492094 | 0.0383119 |
| GOBP_GENE_SILENCING_BY_RNA | 27 | 1.886893 | 0.0492094 | 0.0383119 |
| GOBP_RESPONSE_TO_PEPTIDE | 74 | 1.784201 | 0.0492919 | 0.0383761 |
| ID | setSize | NES | p.adjust | qvalue |
|---|---|---|---|---|
| GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME | 79 | -3.188977 | 0.0000001 | 0.0000001 |
| GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR | 25 | -2.913449 | 0.0000317 | 0.0000277 |
| GOMF_OXIDOREDUCTION_DRIVEN_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 34 | -2.872495 | 0.0000317 | 0.0000277 |
| GOMF_NADH_DEHYDROGENASE_ACTIVITY | 22 | -2.804994 | 0.0001147 | 0.0001004 |
| GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H | 27 | -2.757845 | 0.0001527 | 0.0001336 |
| GOMF_SEQUENCE_SPECIFIC_DNA_BINDING | 204 | 2.161929 | 0.0001527 | 0.0001336 |
| GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY | 132 | 2.239072 | 0.0002665 | 0.0002331 |
| GOMF_CIS_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING | 120 | 2.263349 | 0.0002898 | 0.0002535 |
| GOMF_ELECTRON_TRANSFER_ACTIVITY | 44 | -2.635098 | 0.0003119 | 0.0002728 |
| GOMF_STRUCTURAL_MOLECULE_ACTIVITY | 117 | -2.279298 | 0.0003119 | 0.0002728 |
| GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY | 228 | 1.997992 | 0.0005922 | 0.0005180 |
| GOMF_TRANSPORTER_ACTIVITY | 141 | -2.159188 | 0.0008350 | 0.0007303 |
| GOMF_DNA_BINDING_TRANSCRIPTION_ACTIVATOR_ACTIVITY | 50 | 2.301884 | 0.0011857 | 0.0010371 |
| GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 43 | -2.420557 | 0.0016916 | 0.0014796 |
| GOMF_RRNA_BINDING | 22 | -2.125691 | 0.0439659 | 0.0384556 |
| ID | setSize | NES | p.adjust | qvalue |
|---|---|---|---|---|
| REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS | 57 | -2.914298 | 0.0000390 | 0.0000371 |
| REACTOME_COMPLEX_I_BIOGENESIS | 24 | -2.745282 | 0.0003135 | 0.0002980 |
| REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION | 50 | -2.683024 | 0.0003135 | 0.0002980 |
| REACTOME_INFLUENZA_INFECTION | 61 | -2.627043 | 0.0003135 | 0.0002980 |
| REACTOME_TRANSLATION | 122 | -2.405331 | 0.0003135 | 0.0002980 |
| REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | 46 | -2.633468 | 0.0003681 | 0.0003500 |
| REACTOME_THE_CITRIC_ACID_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT | 67 | -2.430707 | 0.0012242 | 0.0011638 |
| REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | 58 | -2.441586 | 0.0012949 | 0.0012311 |
| REACTOME_MITOCHONDRIAL_TRANSLATION | 36 | -2.599831 | 0.0014253 | 0.0013550 |
| REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY | 52 | -2.387285 | 0.0019799 | 0.0018823 |
| REACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS | 76 | -2.276734 | 0.0030012 | 0.0028532 |
| REACTOME_CELLULAR_RESPONSE_TO_STARVATION | 65 | -2.255515 | 0.0032817 | 0.0031199 |
| REACTOME_RRNA_PROCESSING | 90 | -2.178627 | 0.0032817 | 0.0031199 |
| REACTOME_SELENOAMINO_ACID_METABOLISM | 53 | -2.222195 | 0.0060371 | 0.0057393 |
| REACTOME_SIGNALING_BY_ROBO_RECEPTORS | 80 | -2.085943 | 0.0086215 | 0.0081963 |
| REACTOME_TOLL_LIKE_RECEPTOR_CASCADES | 23 | 2.145401 | 0.0160538 | 0.0152621 |
| REACTOME_NEURONAL_SYSTEM | 32 | -2.181792 | 0.0258105 | 0.0245375 |
| REACTOME_NONSENSE_MEDIATED_DECAY_NMD | 59 | -2.121582 | 0.0258105 | 0.0245375 |
| REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF | 16 | 2.046887 | 0.0258105 | 0.0245375 |
| REACTOME_EUKARYOTIC_TRANSLATION_INITIATION | 59 | -2.061974 | 0.0307471 | 0.0292307 |
| ID | setSize | NES | p.adjust | qvalue |
|---|---|---|---|---|
| WP_OXIDATIVE_PHOSPHORYLATION | 33 | -3.016538 | 0.0000067 | 0.0000057 |
| WP_ELECTRON_TRANSPORT_CHAIN_OXPHOS_SYSTEM_IN_MITOCHONDRIA | 54 | -2.851399 | 0.0000090 | 0.0000075 |
| WP_MITOCHONDRIAL_COMPLEX_I_ASSEMBLY_MODEL_OXPHOS_SYSTEM | 23 | -2.739863 | 0.0004285 | 0.0003602 |
| WP_CYTOPLASMIC_RIBOSOMAL_PROTEINS | 49 | -2.524652 | 0.0008650 | 0.0007271 |
| WP_GLUCOCORTICOID_RECEPTOR_PATHWAY | 17 | 2.154503 | 0.0126969 | 0.0106722 |
| WP_FRAGILE_X_SYNDROME | 18 | -2.073289 | 0.0400842 | 0.0336921 |
| WP_STEROL_REGULATORY_ELEMENTBINDING_PROTEINS_SREBP_SIGNALING | 20 | 2.066070 | 0.0400842 | 0.0336921 |
| WP_NONALCOHOLIC_FATTY_LIVER_DISEASE | 46 | -1.978519 | 0.0400842 | 0.0336921 |
| WP_NUCLEAR_RECEPTORS_METAPATHWAY | 52 | 1.964658 | 0.0400842 | 0.0336921 |
| WP_SUDDEN_INFANT_DEATH_SYNDROME_SIDS_SUSCEPTIBILITY_PATHWAYS | 17 | 2.030388 | 0.0444559 | 0.0373667 |
| WP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2586 | 13 | 1.986317 | 0.0444559 | 0.0373667 |
| WP_CIRCADIAN_RHYTHM_GENES | 34 | 1.940488 | 0.0444559 | 0.0373667 |
Highlight on the volcano plot of the genes found to be implicated in the antigen presenting pathway + table
| gene | log2FoldChange | padj | description |
|---|---|---|---|
| RAB8B | 1.3082949 | 0.0000000 | RAB8B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:30273] |
| RAB35 | 0.9675892 | 0.0000000 | RAB35, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9774] |
| LNPEP | 1.1727759 | 0.0000000 | leucyl and cystinyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:6656] |
| ARL8B | 0.7914131 | 0.0000000 | ADP ribosylation factor like GTPase 8B [Source:HGNC Symbol;Acc:HGNC:25564] |
| PIKFYVE | 0.8594568 | 0.0000001 | phosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785] |
| CTSD | -0.6241187 | 0.0000027 | cathepsin D [Source:HGNC Symbol;Acc:HGNC:2529] |
| ERAP2 | -0.8017025 | 0.0000048 | endoplasmic reticulum aminopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:29499] |
| RAB33A | 1.3929028 | 0.0000133 | RAB33A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9773] |
| RAB6A | 0.5461231 | 0.0000417 | RAB6A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9786] |
| MICA | -0.6871788 | 0.0000464 | MHC class I polypeptide-related sequence A [Source:HGNC Symbol;Acc:HGNC:7090] |
| FCGR1A | -1.0134651 | 0.0001062 | Fc gamma receptor Ia [Source:HGNC Symbol;Acc:HGNC:3613] |
| ERAP1 | 0.5559485 | 0.0005007 | endoplasmic reticulum aminopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:18173] |
Table of the genes that could be found as proteins in the significantly enriched peptides in the immunopeptidomic data.
## [1] 36 11
| gene | log2FoldChange | padj | description |
|---|---|---|---|
| KRTCAP2 | -1.5021573 | 0.0000000 | keratinocyte associated protein 2 [Source:HGNC Symbol;Acc:HGNC:28942] |
| PRTN3 | -1.2107807 | 0.0000000 | proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495] |
| METAP2 | 1.1040167 | 0.0000000 | methionyl aminopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:16672] |
| RPL35 | -1.1732016 | 0.0000000 | ribosomal protein L35 [Source:HGNC Symbol;Acc:HGNC:10344] |
| ELANE | -1.2322149 | 0.0000000 | elastase, neutrophil expressed [Source:HGNC Symbol;Acc:HGNC:3309] |
| PXK | 1.1528337 | 0.0000000 | PX domain containing serine/threonine kinase like [Source:HGNC Symbol;Acc:HGNC:23326] |
| RBMX | 0.9197177 | 0.0000000 | RNA binding motif protein X-linked [Source:HGNC Symbol;Acc:HGNC:9910] |
| PPP1R27 | -1.4553395 | 0.0000000 | protein phosphatase 1 regulatory subunit 27 [Source:HGNC Symbol;Acc:HGNC:16813] |
| PMF1 | -0.8998079 | 0.0000000 | polyamine modulated factor 1 [Source:HGNC Symbol;Acc:HGNC:9112] |
| ATP5PF | -0.9758286 | 0.0000000 | ATP synthase peripheral stalk subunit F6 [Source:HGNC Symbol;Acc:HGNC:847] |
| TSTD2 | 2.0711363 | 0.0000000 | thiosulfate sulfurtransferase like domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30087] |
| TGS1 | 1.1872364 | 0.0000000 | trimethylguanosine synthase 1 [Source:HGNC Symbol;Acc:HGNC:17843] |
| PRPF31 | -0.9557415 | 0.0000000 | pre-mRNA processing factor 31 [Source:HGNC Symbol;Acc:HGNC:15446] |
| TXNIP | 1.2337513 | 0.0000000 | thioredoxin interacting protein [Source:HGNC Symbol;Acc:HGNC:16952] |
| DNAJA2 | 1.0801674 | 0.0000000 | DnaJ heat shock protein family (Hsp40) member A2 [Source:HGNC Symbol;Acc:HGNC:14884] |
| BCLAF1 | 0.6766773 | 0.0000000 | BCL2 associated transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16863] |
| RPS17 | -0.7267731 | 0.0000000 | ribosomal protein S17 [Source:HGNC Symbol;Acc:HGNC:10397] |
| TRIM13 | -0.7992741 | 0.0000000 | tripartite motif containing 13 [Source:HGNC Symbol;Acc:HGNC:9976] |
| LNPEP | 1.1727759 | 0.0000000 | leucyl and cystinyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:6656] |
| MTA2 | -0.7637732 | 0.0000000 | metastasis associated 1 family member 2 [Source:HGNC Symbol;Acc:HGNC:7411] |
| NA | 3.2170778 | 0.0000000 | novel transcript |
| RPL34 | -0.7593908 | 0.0000000 | ribosomal protein L34 [Source:HGNC Symbol;Acc:HGNC:10340] |
| NA | 4.5353284 | 0.0000003 | novel transcript, antisense to RPTOR |
| PPT1 | 1.1207877 | 0.0000003 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] |
| ATP5F1B | 0.8913198 | 0.0000003 | ATP synthase F1 subunit beta [Source:HGNC Symbol;Acc:HGNC:830] |
| TUBB4B | -0.8346326 | 0.0000007 | tubulin beta 4B class IVb [Source:HGNC Symbol;Acc:HGNC:20771] |
| ABHD17B | 0.8712265 | 0.0000041 | abhydrolase domain containing 17B, depalmitoylase [Source:HGNC Symbol;Acc:HGNC:24278] |
| METAP1 | 0.5845978 | 0.0000131 | methionyl aminopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:15789] |
| GFPT1 | 0.7942751 | 0.0000173 | glutamine–fructose-6-phosphate transaminase 1 [Source:HGNC Symbol;Acc:HGNC:4241] |
| CIRBP | -0.4092358 | 0.0002673 | cold inducible RNA binding protein [Source:HGNC Symbol;Acc:HGNC:1982] |
| COPZ1 | -0.4227278 | 0.0003366 | COPI coat complex subunit zeta 1 [Source:HGNC Symbol;Acc:HGNC:2243] |
| CAD | -0.5876069 | 0.0003795 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [Source:HGNC Symbol;Acc:HGNC:1424] |
| CDK17 | 0.6835569 | 0.0005126 | cyclin dependent kinase 17 [Source:HGNC Symbol;Acc:HGNC:8750] |
| FASN | 0.4674484 | 0.0007743 | fatty acid synthase [Source:HGNC Symbol;Acc:HGNC:3594] |
| PSMD7 | 0.5346745 | 0.0008086 | proteasome 26S subunit, non-ATPase 7 [Source:HGNC Symbol;Acc:HGNC:9565] |
| HNRNPDL | 0.3766856 | 0.0009490 | heterogeneous nuclear ribonucleoprotein D like [Source:HGNC Symbol;Acc:HGNC:5037] |
## [1] 19 11
| gene | log2FoldChange | padj | description |
|---|---|---|---|
| CD63 | -1.0314250 | 0.0000000 | CD63 molecule [Source:HGNC Symbol;Acc:HGNC:1692] |
| LMAN1 | 1.1586409 | 0.0000000 | lectin, mannose binding 1 [Source:HGNC Symbol;Acc:HGNC:6631] |
| SRGN | 1.0732210 | 0.0000000 | serglycin [Source:HGNC Symbol;Acc:HGNC:9361] |
| ERP29 | -0.7739467 | 0.0000000 | endoplasmic reticulum protein 29 [Source:HGNC Symbol;Acc:HGNC:13799] |
| FDFT1 | 0.8132262 | 0.0000000 | farnesyl-diphosphate farnesyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3629] |
| SEPTIN6 | 0.8225595 | 0.0000000 | septin 6 [Source:HGNC Symbol;Acc:HGNC:15848] |
| CRELD2 | -0.7833789 | 0.0000000 | cysteine rich with EGF like domains 2 [Source:HGNC Symbol;Acc:HGNC:28150] |
| TMED2 | 0.8504556 | 0.0000000 | transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996] |
| NA | 3.2170778 | 0.0000000 | novel transcript |
| SSR1 | 0.6722112 | 0.0000002 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] |
| NA | 4.5353284 | 0.0000003 | novel transcript, antisense to RPTOR |
| CTDSPL2 | 0.8425381 | 0.0000021 | CTD small phosphatase like 2 [Source:HGNC Symbol;Acc:HGNC:26936] |
| LIPA | 1.1072755 | 0.0000054 | lipase A, lysosomal acid type [Source:HGNC Symbol;Acc:HGNC:6617] |
| NOMO3 | 1.7667326 | 0.0000194 | NODAL modulator 3 [Source:HGNC Symbol;Acc:HGNC:25242] |
| DHX34 | -0.6251980 | 0.0000320 | DExH-box helicase 34 [Source:HGNC Symbol;Acc:HGNC:16719] |
| RPL26 | -0.5912310 | 0.0000644 | ribosomal protein L26 [Source:HGNC Symbol;Acc:HGNC:10327] |
| ALDH1L2 | 0.7364999 | 0.0001866 | aldehyde dehydrogenase 1 family member L2 [Source:HGNC Symbol;Acc:HGNC:26777] |
| BCAP31 | -0.4427626 | 0.0002662 | B cell receptor associated protein 31 [Source:HGNC Symbol;Acc:HGNC:16695] |
| GNS | 0.6935357 | 0.0004480 | glucosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4422] |
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-apple-darwin17.0 (64-bit)
## Running under: macOS Catalina 10.15.7
##
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/4.2/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/4.2/Resources/lib/libRlapack.dylib
##
## locale:
## [1] fr_BE.UTF-8/fr_BE.UTF-8/fr_BE.UTF-8/C/fr_BE.UTF-8/fr_BE.UTF-8
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] readxl_1.4.1 msigdbr_7.5.1 clusterProfiler_4.4.4
## [4] ggrepel_0.9.1 forcats_0.5.2 stringr_1.4.1
## [7] dplyr_1.0.10 purrr_0.3.4 readr_2.1.2
## [10] tidyr_1.2.1 tibble_3.1.8 ggplot2_3.3.6
## [13] tidyverse_1.3.2
##
## loaded via a namespace (and not attached):
## [1] shadowtext_0.1.2 backports_1.4.1 fastmatch_1.1-3
## [4] plyr_1.8.7 igraph_1.3.4 lazyeval_0.2.2
## [7] splines_4.2.1 BiocParallel_1.30.3 GenomeInfoDb_1.32.4
## [10] digest_0.6.29 yulab.utils_0.0.5 htmltools_0.5.3
## [13] GOSemSim_2.22.0 viridis_0.6.2 GO.db_3.15.0
## [16] fansi_1.0.3 magrittr_2.0.3 memoise_2.0.1
## [19] googlesheets4_1.0.1 tzdb_0.3.0 Biostrings_2.64.1
## [22] graphlayouts_0.8.1 modelr_0.1.9 vroom_1.5.7
## [25] enrichplot_1.16.2 colorspace_2.0-3 blob_1.2.3
## [28] rvest_1.0.3 haven_2.5.1 xfun_0.32
## [31] crayon_1.5.1 RCurl_1.98-1.8 jsonlite_1.8.0
## [34] scatterpie_0.1.8 ape_5.6-2 glue_1.6.2
## [37] polyclip_1.10-0 gtable_0.3.1 gargle_1.2.1
## [40] zlibbioc_1.42.0 XVector_0.36.0 BiocGenerics_0.42.0
## [43] scales_1.2.1 DOSE_3.22.1 DBI_1.1.3
## [46] Rcpp_1.0.9 viridisLite_0.4.1 gridGraphics_0.5-1
## [49] tidytree_0.4.0 bit_4.0.4 stats4_4.2.1
## [52] httr_1.4.4 fgsea_1.22.0 RColorBrewer_1.1-3
## [55] ellipsis_0.3.2 pkgconfig_2.0.3 farver_2.1.1
## [58] sass_0.4.2 dbplyr_2.2.1 utf8_1.2.2
## [61] ggplotify_0.1.0 tidyselect_1.1.2 labeling_0.4.2
## [64] rlang_1.0.5 reshape2_1.4.4 AnnotationDbi_1.58.0
## [67] munsell_0.5.0 cellranger_1.1.0 tools_4.2.1
## [70] cachem_1.0.6 downloader_0.4 cli_3.4.0
## [73] generics_0.1.3 RSQLite_2.2.16 broom_1.0.1
## [76] evaluate_0.16 fastmap_1.1.0 yaml_2.3.5
## [79] ggtree_3.4.2 babelgene_22.9 knitr_1.40
## [82] bit64_4.0.5 fs_1.5.2 tidygraph_1.2.2
## [85] KEGGREST_1.36.3 ggraph_2.0.6 nlme_3.1-157
## [88] aplot_0.1.7 DO.db_2.9 xml2_1.3.3
## [91] compiler_4.2.1 rstudioapi_0.14 png_0.1-7
## [94] reprex_2.0.2 treeio_1.20.2 tweenr_2.0.2
## [97] bslib_0.4.0 stringi_1.7.8 highr_0.9
## [100] lattice_0.20-45 Matrix_1.5-1 vctrs_0.4.1
## [103] pillar_1.8.1 lifecycle_1.0.2 jquerylib_0.1.4
## [106] data.table_1.14.2 bitops_1.0-7 patchwork_1.1.2
## [109] qvalue_2.28.0 R6_2.5.1 gridExtra_2.3
## [112] IRanges_2.30.1 codetools_0.2-18 MASS_7.3-57
## [115] assertthat_0.2.1 withr_2.5.0 S4Vectors_0.34.0
## [118] GenomeInfoDbData_1.2.8 parallel_4.2.1 hms_1.1.2
## [121] grid_4.2.1 ggfun_0.0.7 rmarkdown_2.16
## [124] googledrive_2.0.0 ggforce_0.3.4 Biobase_2.56.0
## [127] lubridate_1.8.0